TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

Corticostriatal atrophy is a cardinal manifestation of Huntington’s disease (HD). However, the mechanism(s) by which mutant huntingtin (mHTT) protein contributes to the degeneration of the corticostriatal circuit is not well understood. We recreated the corticostriatal circuit in microfluidic chambe...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhao, Xiaobei, Chen, Xu-Qiao, Han, Eugene, Hu, Yue, Paik, Paul, Ding, Zhiyong, Overman, Julia, Lau, Alice L., Shahmoradian, Sarah H., Chiu, Wah, Thompson, Leslie M., Wu, Chengbiao, Mobley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035849/
https://ncbi.nlm.nih.gov/pubmed/27601642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603020113
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