Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma(†)

BACKGROUND: Aurora kinase A (AURKA) is commonly overexpressed in sarcoma. The inhibition of AURKA by shRNA or by a specific AURKA inhibitor blocks in vitro proliferation of multiple sarcoma subtypes. MLN8237 (alisertib) is a novel oral adenosine triphosphate-competitive AURKA inhibitor. PATIENTS AND...

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Enregistré dans:
Détails bibliographiques
Publié dans:Ann Oncol
Auteurs principaux: Dickson, M. A., Mahoney, M. R., Tap, W. D., D'Angelo, S. P., Keohan, M. L., Van Tine, B. A., Agulnik, M., Horvath, L. E., Nair, J. S., Schwartz, G. K.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035789/
https://ncbi.nlm.nih.gov/pubmed/27502708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw281
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