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Aging of hematopoietic stem cells: DNA damage and mutations?

Aging in the hematopoietic system and the stem cell niche contributes to aging-associated phenotypes of hematopoietic stem cells (HSCs), including leukemia and aging-associated immune remodeling. Among others, the DNA damage theory of aging of HSCs is well established, based on the detection of a si...

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Publicat a:Exp Hematol
Autors principals: Möhrle, Bettina, Geiger, Hartmut
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035607/
https://ncbi.nlm.nih.gov/pubmed/27402537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.06.253
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