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Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps()

Chimeric antigen receptor (CAR) T cell therapy has shown promise in CD19 expressing hematologic malignancies, but how to translate this success to solid malignancies remains elusive. Effective translation of CAR T cells to solid tumors will require an understanding of potential therapeutic barriers,...

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Publicado en:Pharmacol Ther
Autores principales: Beatty, Gregory L., O’Hara, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035606/
https://ncbi.nlm.nih.gov/pubmed/27373504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2016.06.010
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