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CACNA1H missense mutations associated with amyotrophic lateral sclerosis alter Ca(v)3.2 T-type calcium channel activity and reticular thalamic neuron firing

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. In a recent study by Steinberg and colleagues, 2 recessive missense mutations were identified in the Ca(v)3.2 T-type calcium channel gene (CACNA1H), in a family w...

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Detalhes bibliográficos
Publicado no:Channels (Austin)
Main Authors: Rzhepetskyy, Yuriy, Lazniewska, Joanna, Blesneac, Iulia, Pamphlett, Roger, Weiss, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034776/
https://ncbi.nlm.nih.gov/pubmed/27331657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2016.1204497
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