Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla

BACKGROUND: Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrogenase resulting in an accumulation of the “oncometabolite” 2-hydroxyglutarate (...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Verma, Gaurav, Mohan, Suyash, Nasrallah, MacLean P., Brem, Steven, Lee, John Y. K., Chawla, Sanjeev, Wang, Sumei, Nagarajan, Rajakumar, Thomas, M. Albert, Poptani, Harish
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034563/
https://ncbi.nlm.nih.gov/pubmed/27659543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1035-1
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