Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla

BACKGROUND: Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrogenase resulting in an accumulation of the “oncometabolite” 2-hydroxyglutarate (...

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Detalles Bibliográficos
Publicado en:J Transl Med
Autores principales: Verma, Gaurav, Mohan, Suyash, Nasrallah, MacLean P., Brem, Steven, Lee, John Y. K., Chawla, Sanjeev, Wang, Sumei, Nagarajan, Rajakumar, Thomas, M. Albert, Poptani, Harish
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034563/
https://ncbi.nlm.nih.gov/pubmed/27659543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1035-1
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