PET Imaging of Extracellular pH in Tumors with (64)Cu- and (18)F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study

[Image: see text] pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two positron emitti...

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Detalles Bibliográficos
Publicado en:Bioconjug Chem
Main Authors: Demoin, Dustin Wayne, Wyatt, Linden C., Edwards, Kimberly J., Abdel-Atti, Dalya, Sarparanta, Mirkka, Pourat, Jacob, Longo, Valerie A., Carlin, Sean D., Engelman, Donald M., Andreev, Oleg A., Reshetnyak, Yana K., Viola-Villegas, Nerissa, Lewis, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2016
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034329/
https://ncbi.nlm.nih.gov/pubmed/27396694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.6b00306
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