Comparison of γ-Aminobutyric Acid, Type A (GABA(A)), Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS

The subunit stoichiometry and arrangement of synaptic αβγ GABA(A) receptors are generally accepted as 2α:2β:1γ with a β-α-γ-β-α counterclockwise configuration, respectively. Whether extrasynaptic αβδ receptors adopt the analogous β-α-δ-β-α subunit configuration remains controversial. Using flow cyto...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Botzolakis, Emmanuel J., Gurba, Katharine N., Lagrange, Andre H., Feng, Hua-Jun, Stanic, Aleksandar K., Hu, Ningning, Macdonald, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034041/
https://ncbi.nlm.nih.gov/pubmed/27493204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698860
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