A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosus

To date, the major target of biologic therapeutics in systemic lupus erythematosus (SLE) has been the B cell, which produces pathogenic autoantibodies. Recently, targeting type I IFN, which is elaborated by plasmacytoid dendritic cells (pDCs) in response to endosomal TLR7 and TLR9 stimulation by SLE...

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Bibliografiska uppgifter
I publikationen:JCI Insight
Huvudupphovsmän: Oon, Shereen, Huynh, Huy, Tai, Tsin Yee, Ng, Milica, Monaghan, Katherine, Biondo, Mark, Vairo, Gino, Maraskovsky, Eugene, Nash, Andrew D., Wicks, Ian P., Wilson, Nicholas J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033899/
https://ncbi.nlm.nih.gov/pubmed/27699260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86131
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