Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging

Hypertension is nearly universal yet poorly controlled in the elderly despite proven benefits of intensive treatment. Mice lacking mineralocorticoid receptors in smooth muscle cells (SMC-MR-KO) are protected from rising blood pressure (BP) with aging, despite normal renal function. Vasoconstriction...

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Pubblicato in:JCI Insight
Autori principali: DuPont, Jennifer J., McCurley, Amy, Davel, Ana P., McCarthy, Joseph, Bender, Shawn B., Hong, Kwangseok, Yang, Yan, Yoo, Jeung-Ki, Aronovitz, Mark, Baur, Wendy E., Christou, Demetra D., Hill, Michael A., Jaffe, Iris Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033871/
https://ncbi.nlm.nih.gov/pubmed/27683672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88942
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