Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging

Hypertension is nearly universal yet poorly controlled in the elderly despite proven benefits of intensive treatment. Mice lacking mineralocorticoid receptors in smooth muscle cells (SMC-MR-KO) are protected from rising blood pressure (BP) with aging, despite normal renal function. Vasoconstriction...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: DuPont, Jennifer J., McCurley, Amy, Davel, Ana P., McCarthy, Joseph, Bender, Shawn B., Hong, Kwangseok, Yang, Yan, Yoo, Jeung-Ki, Aronovitz, Mark, Baur, Wendy E., Christou, Demetra D., Hill, Michael A., Jaffe, Iris Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033871/
https://ncbi.nlm.nih.gov/pubmed/27683672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88942
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