Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant join...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Lescale, Chloé, Lenden Hasse, Hélène, Blackford, Andrew N., Balmus, Gabriel, Bianchi, Joy J., Yu, Wei, Bacoccina, Léa, Jarade, Angélique, Clouin, Christophe, Sivapalan, Rohan, Reina-San-Martin, Bernardo, Jackson, Stephen P., Deriano, Ludovic
Format: Artigo
Language:Inglês
Published: Cell Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033762/
https://ncbi.nlm.nih.gov/pubmed/27601299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.069
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