Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications

Diabetes is associated with altered cellular metabolism, but how altered metabolism contributes to the development of diabetic complications is unknown. We used the BKS db/db diabetic mouse model to investigate changes in carbohydrate and lipid metabolism in kidney cortex, peripheral nerve, and reti...

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出版年:JCI Insight
主要な著者: Sas, Kelli M., Kayampilly, Pradeep, Byun, Jaeman, Nair, Viji, Hinder, Lucy M., Hur, Junguk, Zhang, Hongyu, Lin, Chengmao, Qi, Nathan R., Michailidis, George, Groop, Per-Henrik, Nelson, Robert G., Darshi, Manjula, Sharma, Kumar, Schelling, Jeffrey R., Sedor, John R., Pop-Busui, Rodica, Weinberg, Joel M., Soleimanpour, Scott A., Abcouwer, Steven F., Gardner, Thomas W., Burant, Charles F., Feldman, Eva L., Kretzler, Matthias, Brosius, Frank C., Pennathur, Subramaniam
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2016
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033761/
https://ncbi.nlm.nih.gov/pubmed/27699244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86976
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