Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications

Diabetes is associated with altered cellular metabolism, but how altered metabolism contributes to the development of diabetic complications is unknown. We used the BKS db/db diabetic mouse model to investigate changes in carbohydrate and lipid metabolism in kidney cortex, peripheral nerve, and reti...

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發表在:JCI Insight
Main Authors: Sas, Kelli M., Kayampilly, Pradeep, Byun, Jaeman, Nair, Viji, Hinder, Lucy M., Hur, Junguk, Zhang, Hongyu, Lin, Chengmao, Qi, Nathan R., Michailidis, George, Groop, Per-Henrik, Nelson, Robert G., Darshi, Manjula, Sharma, Kumar, Schelling, Jeffrey R., Sedor, John R., Pop-Busui, Rodica, Weinberg, Joel M., Soleimanpour, Scott A., Abcouwer, Steven F., Gardner, Thomas W., Burant, Charles F., Feldman, Eva L., Kretzler, Matthias, Brosius, Frank C., Pennathur, Subramaniam
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033761/
https://ncbi.nlm.nih.gov/pubmed/27699244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86976
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