Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications

Diabetes is associated with altered cellular metabolism, but how altered metabolism contributes to the development of diabetic complications is unknown. We used the BKS db/db diabetic mouse model to investigate changes in carbohydrate and lipid metabolism in kidney cortex, peripheral nerve, and reti...

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Published in:JCI Insight
Main Authors: Sas, Kelli M., Kayampilly, Pradeep, Byun, Jaeman, Nair, Viji, Hinder, Lucy M., Hur, Junguk, Zhang, Hongyu, Lin, Chengmao, Qi, Nathan R., Michailidis, George, Groop, Per-Henrik, Nelson, Robert G., Darshi, Manjula, Sharma, Kumar, Schelling, Jeffrey R., Sedor, John R., Pop-Busui, Rodica, Weinberg, Joel M., Soleimanpour, Scott A., Abcouwer, Steven F., Gardner, Thomas W., Burant, Charles F., Feldman, Eva L., Kretzler, Matthias, Brosius, Frank C., Pennathur, Subramaniam
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033761/
https://ncbi.nlm.nih.gov/pubmed/27699244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86976
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