Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy

Transcriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides an outstanding model to study host def...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Inkeles, Megan S., Teles, Rosane M.B., Pouldar, Delila, Andrade, Priscila R., Madigan, Cressida A., Lopez, David, Ambrose, Mike, Noursadeghi, Mahdad, Sarno, Euzenir N., Rea, Thomas H., Ochoa, Maria T., Iruela-Arispe, M. Luisa, Swindell, William R., Ottenhoff, Tom H.M., Geluk, Annemieke, Bloom, Barry R., Pellegrini, Matteo, Modlin, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033757/
https://ncbi.nlm.nih.gov/pubmed/27699251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88843
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