MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Oxidative stress is implicated in various neurodegenerative disorders, including retinitis pigmentosa (RP), an inherited disease that causes blindness. The biological and cellular mechanisms by which oxidative stress mediates neuronal cell death are largely unknown. In a mouse model of RP (rd10 mice...

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Foilsithe in:JCI Insight
Main Authors: Nakatake, Shunji, Murakami, Yusuke, Ikeda, Yasuhiro, Morioka, Noriko, Tachibana, Takashi, Fujiwara, Kohta, Yoshida, Noriko, Notomi, Shoji, Hisatomi, Toshio, Yoshida, Shigeo, Ishibashi, Tatsuro, Nakabeppu, Yusaku, Sonoda, Koh-Hei
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033752/
https://ncbi.nlm.nih.gov/pubmed/27699246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87781
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