MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Oxidative stress is implicated in various neurodegenerative disorders, including retinitis pigmentosa (RP), an inherited disease that causes blindness. The biological and cellular mechanisms by which oxidative stress mediates neuronal cell death are largely unknown. In a mouse model of RP (rd10 mice...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Nakatake, Shunji, Murakami, Yusuke, Ikeda, Yasuhiro, Morioka, Noriko, Tachibana, Takashi, Fujiwara, Kohta, Yoshida, Noriko, Notomi, Shoji, Hisatomi, Toshio, Yoshida, Shigeo, Ishibashi, Tatsuro, Nakabeppu, Yusaku, Sonoda, Koh-Hei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033752/
https://ncbi.nlm.nih.gov/pubmed/27699246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87781
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