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Structural basis for negative allosteric modulation of GluN2A-containing NMDA receptors
NMDA receptors mediate excitatory synaptic transmission and regulate synaptic plasticity in the central nervous system, but their dysregulation is also implicated in numerous brain disorders. Here, we describe GluN2A-selective negative allosteric modulators (NAMs) that inhibit NMDA receptors by stab...
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| Publicado no: | Neuron |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033714/ https://ncbi.nlm.nih.gov/pubmed/27618671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.08.014 |
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