FXR Activation Increases Reverse Cholesterol Transport by Modulating Bile Acid Composition and Cholesterol Absorption

Activation of farnesoid X receptor (FXR) markedly attenuates the development of atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here we show that the FXR agonist obeticholic acid (OCA) increases fecal cholesterol excretion and macrophage reverse cholestero...

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Gepubliceerd in:Hepatology
Hoofdauteurs: Xu, Yang, Li, Fei, Zalzala, Munaf, Xu, Jiesi, Gonzalez, Frank J, Adorini, Luciano, Lee, Yoon-Kwang, Yin, Liya, Zhang, Yanqiao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033696/
https://ncbi.nlm.nih.gov/pubmed/27359351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28712
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