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Mitochondria-Targeted Antioxidant Mito-Tempo Protects against Acetaminophen Hepatotoxicity

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive mitochondrial oxidant stress. However, its importance as a drug target has not been clarified. To investigate this, fasted C57BL/6J mice were treated with 300 mg/kg APAP and the mitochondria-targeted antioxidant Mito-Tempo (MT) was...

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Podrobná bibliografie
Vydáno v:Arch Toxicol
Hlavní autoři: Du, Kuo, Farhood, Anwar, Jaeschke, Hartmut
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033665/
https://ncbi.nlm.nih.gov/pubmed/27002509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1692-0
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