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A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress–Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells
PURPOSE: 5-Lipoxygenase (5-LOX) oxygenates arachidonic acid to form 5-hydroperoxyeicosatetraenoic acid, which is further converted into biologically detrimental leukotrienes, such as leukotriene B4 (LTB(4)). The RPE and retina express the PNPLA2 gene for pigment epithelium–derived factor receptor (P...
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| Publicado no: | Invest Ophthalmol Vis Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Association for Research in Vision and Ophthalmology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033602/ https://ncbi.nlm.nih.gov/pubmed/27635633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-19039 |
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