Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world. Recent evidence suggests that RPE and photoreceptors have an interconnected metabolism and that mitochondrial damage in RPE is a trigger for degeneration in both RPE and photoreceptors in AMD. To test th...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Brown, Emily E., DeWeerd, Alexander J., Ildefonso, Cristhian J., Lewin, Alfred S., Ash, John D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488819/
https://ncbi.nlm.nih.gov/pubmed/31039480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101201
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