Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function

To characterize the mechanisms by which the highly conserved exocyst trafficking complex regulates eye physiology in zebrafish and mice, we focused on Exoc5 (also known as sec10), a central exocyst component. We analyzed both exoc5 zebrafish mutants and retinal pigmented epithelium (RPE)-specific Ex...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Rohrer, Bärbel, Biswal, Manas R., Obert, Elisabeth, Dang, Yujing, Su, Yanhui, Zuo, Xiaofeng, Fogelgren, Ben, Kondkar, Altaf A., Lobo, Glenn P., Lipschutz, Joshua H.
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151988/
https://ncbi.nlm.nih.gov/pubmed/34064901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105083
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