Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function

To characterize the mechanisms by which the highly conserved exocyst trafficking complex regulates eye physiology in zebrafish and mice, we focused on Exoc5 (also known as sec10), a central exocyst component. We analyzed both exoc5 zebrafish mutants and retinal pigmented epithelium (RPE)-specific Ex...

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Pubblicato in:Int J Mol Sci
Autori principali: Rohrer, Bärbel, Biswal, Manas R., Obert, Elisabeth, Dang, Yujing, Su, Yanhui, Zuo, Xiaofeng, Fogelgren, Ben, Kondkar, Altaf A., Lobo, Glenn P., Lipschutz, Joshua H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151988/
https://ncbi.nlm.nih.gov/pubmed/34064901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105083
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