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Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function

To characterize the mechanisms by which the highly conserved exocyst trafficking complex regulates eye physiology in zebrafish and mice, we focused on Exoc5 (also known as sec10), a central exocyst component. We analyzed both exoc5 zebrafish mutants and retinal pigmented epithelium (RPE)-specific Ex...

詳細記述

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書誌詳細
出版年:Int J Mol Sci
主要な著者: Rohrer, Bärbel, Biswal, Manas R., Obert, Elisabeth, Dang, Yujing, Su, Yanhui, Zuo, Xiaofeng, Fogelgren, Ben, Kondkar, Altaf A., Lobo, Glenn P., Lipschutz, Joshua H.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151988/
https://ncbi.nlm.nih.gov/pubmed/34064901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105083
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