SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity

The sarcoendoplasmic reticulum (ER) Ca(2+) ATPase 2 (SERCA2) pump is a P-type ATPase tasked with the maintenance of ER Ca(2+) stores. Whereas β-cell SERCA2 expression is reduced in diabetes, the role of SERCA2 in the regulation of whole-body glucose homeostasis has remained uncharacterized. To this...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Tong, Xin, Kono, Tatsuyoshi, Anderson-Baucum, Emily K., Yamamoto, Wataru, Gilon, Patrick, Lebeche, Djamel, Day, Richard N., Shull, Gary E., Evans-Molina, Carmella
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2016
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033263/
https://ncbi.nlm.nih.gov/pubmed/27489309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0084
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