Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell

Store-operated Ca(2+) entry (SOCE) is a dynamic process that leads to refilling of endoplasmic reticulum (ER) Ca(2+) stores through reversible gating of plasma membrane Ca(2+) channels by the ER Ca(2+) sensor Stromal Interaction Molecule 1 (STIM1). Pathogenic reductions in β-cell ER Ca(2+) have been...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Kono, Tatsuyoshi, Tong, Xin, Taleb, Solaema, Bone, Robert N., Iida, Hitoshi, Lee, Chih-Chun, Sohn, Paul, Gilon, Patrick, Roe, Michael W., Evans-Molina, Carmella
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198337/
https://ncbi.nlm.nih.gov/pubmed/30131394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1351
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados