Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Bedaquiline (a.k.a., Sirturo) is an anti-microbial agent, which is approved by the FDA for the treatment of multi-drug resistant pulmonary tuberculosis (TB). Bedaquiline is a first-in-class diaryl-quinoline compound, that mechanistically inhibits the bacterial ATP-synthase, and shows potent activity...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Fiorillo, Marco, Lamb, Rebecca, Tanowitz, Herbert B., Cappello, Anna Rita, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032685/
https://ncbi.nlm.nih.gov/pubmed/27344270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.100983
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