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Accounting for selection and correlation in the analysis of two-stage genome-wide association studies

The problem of selection bias has long been recognized in the analysis of two-stage trials, where promising candidates are selected in stage 1 for confirmatory analysis in stage 2. To efficiently correct for bias, uniformly minimum variance conditionally unbiased estimators (UMVCUEs) have been propo...

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Vydáno v:Biostatistics
Hlavní autoři: Robertson, David S., Prevost, A. Toby, Bowden, Jack
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031943/
https://ncbi.nlm.nih.gov/pubmed/26993061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxw012
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