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Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis‐driven selection rules
Seamless phase II/III clinical trials offer an efficient way to select an experimental treatment and perform confirmatory analysis within a single trial. However, combining the data from both stages in the final analysis can induce bias into the estimates of treatment effects. Methods for bias adjus...
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| Publicado no: | Stat Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026174/ https://ncbi.nlm.nih.gov/pubmed/27103068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6974 |
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