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Optimizing the data combination rule for seamless phase II/III clinical trials

We consider seamless phase II/III clinical trials that compare K treatments with a common control in phase II then test the most promising treatment against control in phase III. The final hypothesis test for the selected treatment can use data from both phases, subject to controlling the familywise...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Hampson, Lisa V, Jennison, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288236/
https://ncbi.nlm.nih.gov/pubmed/25315892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6316
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