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Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium

BACKGROUND: Exacerbations of asthma and COPD are triggered by rhinoviruses. Uncontrolled inflammatory pathways, pathogenic bacterial burden and impaired antiviral immunity are thought to be important factors in disease severity and duration. Macrolides including azithromycin are often used to treat...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Porter, James D., Watson, Jennifer, Roberts, Lee R., Gill, Simren K., Groves, Helen, Dhariwal, Jaideep, Almond, Mark H., Wong, Ernie, Walton, Ross P., Jones, Lyn H., Tregoning, John, Kilty, Iain, Johnston, Sebastian L., Edwards, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031920/
https://ncbi.nlm.nih.gov/pubmed/27494903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw222
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