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A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering
Glycosylation is a critical quality attribute of most recombinant biotherapeutics. Consequently, drug development requires careful control of glycoforms to meet bioactivity and biosafety requirements. However, glycoengineering can be extraordinarily difficult given the complex reaction networks unde...
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| Publié dans: | Metab Eng |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5031499/ https://ncbi.nlm.nih.gov/pubmed/26537759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2015.10.007 |
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