Allosteric Optical Control of a Class B G‐Protein‐Coupled Receptor

Allosteric regulation promises to open up new therapeutic avenues by increasing drug specificity at G‐protein‐coupled receptors (GPCRs). However, drug discovery efforts are at present hampered by an inability to precisely control the allosteric site. Herein, we describe the design, synthesis, and te...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Broichhagen, Johannes, Johnston, Natalie R., von Ohlen, Yorrick, Meyer‐Berg, Helena, Jones, Ben J., Bloom, Stephen R., Rutter, Guy A., Trauner, Dirk, Hodson, David J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031193/
https://ncbi.nlm.nih.gov/pubmed/27059784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201600957
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