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Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism

Mitochondria house metabolic pathways that impact most aspects of cellular physiology. While metabolite profiling by mass spectrometry is widely applied at the whole-cell level, it is not routinely possible to measure the concentrations of small molecules in mammalian organelles. We describe a metho...

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Publicat a:Cell
Autors principals: Chen, Walter W., Freinkman, Elizaveta, Wang, Tim, Birsoy, Kıvanç, Sabatini, David M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030821/
https://ncbi.nlm.nih.gov/pubmed/27565352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.07.040
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