Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression

HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we evaluate the impact on viral control and disease progression of transmitted polymorphisms that were either preadapted to or nonassociated with the new host’s HLA. In a cohort of 169 Zambian heterosexual transmission...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Mónaco, Daniela C., Dilernia, Dario A., Fiore-Gartland, Andrew, Yu, Tianwei, Prince, Jessica L., Dennis, Kristine K., Qin, Kai, Schaefer, Malinda, Claiborne, Daniel T., Kilembe, William, Tang, Jianming, Price, Matt A., Farmer, Paul, Gilmour, Jill, Bansal, Anju, Allen, Susan, Goepfert, Paul, Hunter, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030801/
https://ncbi.nlm.nih.gov/pubmed/27551154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151984
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