Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression

HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we evaluate the impact on viral control and disease progression of transmitted polymorphisms that were either preadapted to or nonassociated with the new host’s HLA. In a cohort of 169 Zambian heterosexual transmission...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Exp Med
Κύριοι συγγραφείς: Mónaco, Daniela C., Dilernia, Dario A., Fiore-Gartland, Andrew, Yu, Tianwei, Prince, Jessica L., Dennis, Kristine K., Qin, Kai, Schaefer, Malinda, Claiborne, Daniel T., Kilembe, William, Tang, Jianming, Price, Matt A., Farmer, Paul, Gilmour, Jill, Bansal, Anju, Allen, Susan, Goepfert, Paul, Hunter, Eric
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Rockefeller University Press 2016
Θέματα:
Research Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030801/
https://ncbi.nlm.nih.gov/pubmed/27551154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151984
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