Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression

HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we evaluate the impact on viral control and disease progression of transmitted polymorphisms that were either preadapted to or nonassociated with the new host’s HLA. In a cohort of 169 Zambian heterosexual transmission...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Mónaco, Daniela C., Dilernia, Dario A., Fiore-Gartland, Andrew, Yu, Tianwei, Prince, Jessica L., Dennis, Kristine K., Qin, Kai, Schaefer, Malinda, Claiborne, Daniel T., Kilembe, William, Tang, Jianming, Price, Matt A., Farmer, Paul, Gilmour, Jill, Bansal, Anju, Allen, Susan, Goepfert, Paul, Hunter, Eric
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2016
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030801/
https://ncbi.nlm.nih.gov/pubmed/27551154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151984
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