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Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression
Intraneuronal calcium stimulates the calpain-dependent conversion of p35 to p25, a CDK5 activator. It is widely believed that amyloid β peptide (Aβ) induces this conversion that, in turn, has an essential role in Alzheimer's disease pathogenesis. However, in vivo studies on p25 generation used...
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| Udgivet i: | J Neurosci |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030353/ https://ncbi.nlm.nih.gov/pubmed/27656030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1907-16.2016 |
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