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Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
Although, a number of pathogenic mutations have been found for Alzheimer’s disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3′-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-i...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935712/ https://ncbi.nlm.nih.gov/pubmed/29728560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04238-0 |
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