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Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug
PURPOSE: This study was aimed to develop a novel Histidine-Leucine-Lopinavir (His-Leu-LPV) dipeptide prodrug and evaluate its potential for circumvention of P-gp and MRP2-mediated efflux of lopinavir (LPV) indicated for HIV-1 infection. METHODS: His-Leu-LPV was synthesized following esterification o...
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| Publicat a: | Int J Pharm |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030192/ https://ncbi.nlm.nih.gov/pubmed/27543355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2016.08.027 |
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