Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration mutagenesis. After entering the nucleus, uracilated v...

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Pubblicato in:eLife
Autori principali: Hansen, Erik C, Ransom, Monica, Hesselberth, Jay R, Hosmane, Nina N, Capoferri, Adam A, Bruner, Katherine M, Pollack, Ross A, Zhang, Hao, Drummond, Michael Bradley, Siliciano, Janet M, Siliciano, Robert, Stivers, James T
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030084/
https://ncbi.nlm.nih.gov/pubmed/27644592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18447
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