Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation

Inactivation of Ras GTPase activating proteins (RasGAPs) can activate Ras, increasing the risk for tumor development. Utilizing a melanoma whole genome sequencing (WGS) data from 13 patients, we identified two novel, clustered somatic missense mutations (Y472H and L481F) in RASA1 (RAS p21 protein ac...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sung, Hyeran, Kanchi, Krishna L., Wang, Xue, Hill, Kristen S., Messina, Jane L., Lee, Ji-Hyun, Kim, Youngchul, Dees, Nathan D., Ding, Li, Teer, Jamie K., Yang, Shengyu, Sarnaik, Amod A., Sondak, Vernon K., Mulé, James J., Wilson, Richard K., Weber, Jeffrey S., Kim, Minjung
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029671/
https://ncbi.nlm.nih.gov/pubmed/26993606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8127
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