The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia

The first-in-class compound MLN4924 is a small molecule inhibitor that selectively inactivates NEDD8-activating enzyme (NAE). The anticancer effects of MLN4924 have been attributed to impaired neddylation of Cullin proteins. Here, we show that treatment of T-cell acute lymphoblastic leukemia (T-ALL)...

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Pubblicato in:Oncotarget
Autori principali: Han, Kun, Wang, Qingyang, Cao, Huanling, Qiu, Guihua, Cao, Junxia, Li, Xin, Wang, Jing, Shen, Beifen, Zhang, Jiyan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029665/
https://ncbi.nlm.nih.gov/pubmed/26993774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8068
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