The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma

Uveal melanoma (UM) is the most frequent malignant ocular tumor in adults. While the primary tumor is efficiently treated by surgery and/or radiotherapy, about one third of UM patients develop metastases, for which no effective treatment is currently available. The PKC, MAPK and PI3K/AKT/mTOR signal...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Amirouchene-Angelozzi, Nabil, Frisch-Dit-Leitz, Estelle, Carita, Guillaume, Dahmani, Ahmed, Raymondie, Chloé, Liot, Géraldine, Gentien, David, Némati, Fariba, Decaudin, Didier, Roman-Roman, Sergio, Schoumacher, Marie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029652/
https://ncbi.nlm.nih.gov/pubmed/26988753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8054
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