Telomere length predicts replicative capacity of human fibroblasts.

When human fibroblasts from different donors are grown in vitro, only a small fraction of the variation in their finite replicative capacity is explained by the chronological age of the donor. Because we had previously shown that telomeres, the terminal guanine-rich sequences of chromosomes, shorten...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Allsopp, R C, Vaziri, H, Patterson, C, Goldstein, S, Younglai, E V, Futcher, A B, Greider, C W, Harley, C B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50288/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10114
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