Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of telomeric DNA from the ends of human chromosomes with each somatic cell division eventually reaches a critical point that triggers cellular senescen...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44916/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.9857 |
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