Stable platelet production via the bypass pathway explains long-term hematopoietic stem cell reconstitution

Summary: In vivo differentiation pathways into several blood cell lineages of Hematopoietic stem cells (HSCs) remain challenging to track over time. Using data from single-cell transplantation assays and mathematical modeling, we examined HSC differentiation kinetics, including the myeloid bypass pa...

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Detalhes bibliográficos

Principais autores:	Shoya Iwanami, Toshiko Sato, Hiroshi Haeno, Longchen Xu, Keimyo Imamura, Jun Ooehara, Xun Lan, Hiromitsu Nakauchi, Shingo Iwami, Ryo Yamamoto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-06-01
coleção:	iScience
Assuntos:	Stem cells research Mathematical biosciences Biological constraints
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004225008089
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