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The role of wild type RAS isoforms in cancer
Mutationally activated RAS proteins are critical oncogenic drivers in nearly 30% of all human cancers. As with mutant RAS, the role of wild type RAS proteins in oncogenesis, tumour maintenance and metastasis is context-dependent. Complexity is introduced by the existence of multiple RAS genes (HRAS,...
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| Veröffentlicht in: | Semin Cell Dev Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5028303/ https://ncbi.nlm.nih.gov/pubmed/27422332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2016.07.012 |
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