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RAS isoforms and mutations in cancer at a glance

RAS proteins (KRAS4A, KRAS4B, NRAS and HRAS) function as GDP–GTP-regulated binary on-off switches, which regulate cytoplasmic signaling networks that control diverse normal cellular processes. Gain-of-function missense mutations in RAS genes are found in ∼25% of human cancers, prompting interest in...

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Bibliografske podrobnosti
izdano v:J Cell Sci
Main Authors: Hobbs, G. Aaron, Der, Channing J., Rossman, Kent L.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869631/
https://ncbi.nlm.nih.gov/pubmed/26985062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.182873
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