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RAS isoforms and mutations in cancer at a glance
RAS proteins (KRAS4A, KRAS4B, NRAS and HRAS) function as GDP–GTP-regulated binary on-off switches, which regulate cytoplasmic signaling networks that control diverse normal cellular processes. Gain-of-function missense mutations in RAS genes are found in ∼25% of human cancers, prompting interest in...
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| Publicado no: | J Cell Sci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4869631/ https://ncbi.nlm.nih.gov/pubmed/26985062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.182873 |
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