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RAS isoforms and mutations in cancer at a glance
RAS proteins (KRAS4A, KRAS4B, NRAS and HRAS) function as GDP–GTP-regulated binary on-off switches, which regulate cytoplasmic signaling networks that control diverse normal cellular processes. Gain-of-function missense mutations in RAS genes are found in ∼25% of human cancers, prompting interest in...
Shranjeno v:
izdano v: | J Cell Sci |
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Main Authors: | , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
The Company of Biologists Ltd
2016
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4869631/ https://ncbi.nlm.nih.gov/pubmed/26985062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.182873 |
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