Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies

There is intense interest in developing therapeutic strategies for RAS proteins, the most frequently mutated oncogene family in cancer. Development of effective anti-RAS therapies will be aided by the greater appreciation of RAS isoform-specific differences in signaling events that support neoplasti...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Waters, Andrew M., Ozkan-Dagliyan, Irem, Vaseva, Angelina V., Fer, Nicole, Strathern, Leslie A., Hobbs, G. Aaron, Tessier-Cloutier, Basile, Gillette, William K., Bagni, Rachel, Whiteley, Gordon R., Hartley, James L., McCormick, Frank, Cox, Adrienne D., Houghton, Peter J., Huntsman, David G., Philips, Mark R., Der, Channing J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812265/
https://ncbi.nlm.nih.gov/pubmed/28951536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao3332
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